Synthesis of optically active γ-trimethylsilyl-β,γ-epoxy tertiary alcohols by the diastereoselective addition reaction of β-trimethylsilyl-α, β-epoxyketones with Grignard reagents

Article abstract of DOI:10.1016/S0040-4039(00)93556-1

The reaction of β-trimethylsilyl-α,β-epoxyketones, readily prepared in a chiral form by using the Sharpless kinetic resolution of γ-trimethylsilyl secondary allylic alcohols as a key reaction, with Grignard reagents proceeds highly diastereoselectivity to