(Aminoalkyl)carbamates of Forskolin: Intermediates for the Synthesis of Functionalized Derivatives of Forskolin with Different Specificities for Adenylyl Cyclase and the Glucose Transporter

DOI: 10.1021/jm00115a009

Source and publish data:

Journal of Medicinal Chemistry p. 3204 - 3212 (1991)

Update date:2022-07-29

Topics:

Authors:

Robbins, Joan D.

Laurenza, Antonio

Kosley, Raymond W.

O'Malley, Gerard J.

Spahl, Bettina

Seamon, Kenneth B.

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Article abstract of DOI:10.1021/jm00115a009

(Aminoalkyl)carbamates of forskolin were synthesized at the 6- and 7-hydroxyl positions of forskolin with the length of the alkyl chain varying from ethyl to heptyl.Two of these derivatives, 7-<<(2-aminoethyl)amino>carbonyl>-7-desacetylforskolin (2) and 6

Full text of DOI:10.1021/jm00115a009

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