Carbohydrate Research p. 107 - 118 (1986)
Update date:2022-07-30
Topics:
Szarek, Walter A.
Hay, George W.
Doboszewski, Bogdan
Perlmutter, Milton M.
The reaction of 1,2-anhydro-3,4:4,5-di-O-isopropylidene-1-C-nitro-D-mannitol (2) with potassium hydrogenfluoride in ethylene glycol under anhydrous conditions provides a route to 2-deoxy-2-fluoro-D-glucose, the (18)F-labeled analog of which is an important radiopharmaceutical of use in medical imaging.The reaction is accompained to a minor extent by epimerization at C-2 of the initially formed fluoro aldehyde and also results in attack by solvent at C-2 in 2.
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(1991)
