Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4- arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2- buten-2-yl carbamates

Article abstract of DOI:10.1021/jm00115a004

In an attempt to determine some of the structural features of geiparvarin (1) that account for its cytostatic activity in vitro, a series of geiparvarin analogues (10a-i, l, 12, and 14-16) which contain novel modifications in the region of the olefinic do