Bioorganic and Medicinal Chemistry Letters p. 1989 - 1994 (2012)
Update date:2022-08-05
Topics:
Gentile, Gabriella
Merlo, Giancarlo
Pozzan, Alfonso
Bernasconi, Giovanni
Bax, Benjamin
Bamborough, Paul
Bridges, Angela
Carter, Paul
Neu, Margarete
Yao, Gang
Brough, Caroline
Cutler, Geoffrey
Coffin, Aaron
Belyanskaya, Svetlana
5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described.
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