Highly efficient and general method for synthesis of tertiary allylic alcohols in a chiral form. Synthesis of arbaprostil

DOI: 10.1016/S0040-4039(00)93557-3

Source and publish data:

Tetrahedron Letters p. 5793 - 5796 (1991)

Update date:2022-08-04

Topics:

Authors:

Okamoto, Sentaro

Yoshino, Toshiharu

Tsujiyama, Hiromi

Sato, Fumie

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Article abstract of DOI:10.1016/S0040-4039(00)93557-3

Highly efficient and general method for synthesis of optically active tertiary allylic alcohols (1) starting from readily available optically active γ-trimethylsilyl-β,γ-epoxy tertiary alcohols (3), and the application of the reaction product to the synthesis of arbaprostil are described.

Full text of DOI:10.1016/S0040-4039(00)93557-3

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Product name:(E)-(S)-3-Methyl-1-phenylsulfanyl-hept-1-en-3-ol

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