A new group of antibiotics, hydroxamic acid antimycotic antibiotics. IV. Structures of enactins Ia, Ib1, Ib2 and Va

Article abstract of DOI:10.1248/cpb.39.1436

Structures of enactins Ia, Ib₁, Ib₂ and Va were determined by spectroscopic studies using their bis-2,4-dinitrophenyl derivatives. Both enactins and neoenactins contain L-serine to form the hydroxamic acid structure. Their physico-chemical and biological properties are closely related. The structures of neoenactin congeners have been previously reported and enactins Ia and Va are proved to be 19-hydroxyneoenactin B₂ and 14-dihydroneoenactin M₁, respectively. Both enactins Ib₁ and Ib₂ are determined to be 19-hydroxyneoenactin B₁ and considered to be diastereoisomers at the 19-position, though their steric structures at this position remain to be determined.

Full text of DOI:10.1248/cpb.39.1436

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