Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors

DOI: 10.1016/j.bmcl.2012.02.070

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2843 - 2849 (2012)

Update date:2022-08-05

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Authors:

Basu, Sujay

Prasad, Uppuleti Viplava

Barawkar, Dinesh A.

De, Siddhartha

Palle, Venkata P.

Menon, Suraj

Patel, Meena

Thorat, Sachin

Singh, Umesh P.

Sarma, Koushik Das

Waman, Yogesh

Niranjan, Sanjay

Pathade, Vishal

Gaur, Ashwani

Reddy, Satyanarayana

Ansari, Shariq

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Article abstract of DOI:10.1016/j.bmcl.2012.02.070

A series of novel heterocyclic carboxylic acid based protein tyrosine phosphatase 1B (PTP1B) inhibitors with hydrophobic tail have been synthesized and characterized. Structure-activity relationship (SAR) optimization resulted in identification of several

Full text of DOI:10.1016/j.bmcl.2012.02.070

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