GUAIANE ESTERS FROM THAPSIA VILLOSA

Article abstract of DOI:10.1016/S0031-9422(00)98237-2

Three new terpenes have been isolated from Thapsia villosa var. minor <2n=22 (=2x)> and, mainly by spectroscopic methods, shown to be monoesters of the novel sesquiterpene alcohol (4S,5S,7S,8S)-1(10)-guaiene-8,11-diol.The acid moieties are p-coumaric acid, ferulic acid and senecioic acid, respectively.X-Ray analysis of the 8-O-(S)-1-phenylethylcarbamoyl derivative of the parent guaienediol established the relative and absolute configuration.The chemotaxonomic value of the heterogeneity of terpenes found in different specimens within the species T. villosa is discussed.Key Word Index - Thapsia villosa; Umbelliferae; sesquiterpene esters; phenylethylcarbamate; absolute configuration.