Tetrahedron Letters p. 7373 - 7376 (1998)
Update date:2022-08-03
Topics: Characterization Optimization Structure-Activity Relationship (SAR) Analysis Biological Assays Synthetic Route Design Literature Review Publication and Patenting Toxicity and ADME Studies Target Identification and Validation Further Preclinical Studies Synthesis of Intermediates
Li, Wen-Ren
Peng, Shao-Zheng
The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, α- keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described.
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