Asymmetric synthesis of β-lactams via amine additions to 5(R)-menthyloxy-2[5H]-furanone

DOI: 10.1016/S0957-4166(00)80457-7

Source and publish data:

Tetrahedron Asymmetry p. 775 - 778 (1991)

Update date:2022-08-03

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Authors:

Lubben Lubben

Feringa Feringa

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Article abstract of DOI:10.1016/S0957-4166(00)80457-7

The enantioselective synthesis of a N-benzyl substituted β-lactam 5a, a precursor for carbapenem antibiotics, starting from the chiral synthon 5(R)-menthyloxy-2[5H]-furanone 1, is described.

Full text of DOI:10.1016/S0957-4166(00)80457-7

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Product name:(R)-4,4-Dimethoxy-3-((S)-1-phenyl-ethylamino)-butyric acid methyl ester

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