A one-pot, efficient synthesis of polyfunctionalized pyrido[2,3-d] pyrimidines and uncyclized adducts by aldehydes, 1,3-dicarbonyl compounds, and 6-aminouracils

Article abstract of DOI:10.1002/jhet.1704

A one-pot, efficient protocol for the synthesis of polyfunctionalized pyrido[2,3-d]pyrimidines and uncyclized adducts by 6-aminouracils in poly(ethylene glycol) 200/H₂O or AcOH was described. An interesting family of pyrido[2,3-d]pyrimidines and uncyclized adducts bearing fused pharmacological active units are prepared. The reaction is free of toxic solvents and catalysts, has simple workup procedure, and has high atom economy, making it more environmentally friendly and suitable for large-scale operations.