Antitumor agents. 124. New 4β-substituted aniline derivatives of 6,7-O,O- demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

Article abstract of DOI:10.1021/jm00083a010

A series of 6,7-O,O-demethylene-4'-O-demethyl-4β-(substituted anilino)-4- desoxypodophyllotoxins (18-23), 6,7-O,O-demethylene-6,7-O,O-dimethyl-4'-O- demethyl-4β-(substituted anilino)-4-desoxypodophyllotoxins (28-31), and their corresponding 4'-O-methyl an