1-(2-CHLOROETHOXYETHYL GROUP FOR THE PROTECTION OF 2'-HYDROXYL GROUP IN THE SYNTHESIS OF OLIGORIBONUCLEOTIDES

DOI: 10.1016/S0040-4039(01)93894-8

Source and publish data:

Tetrahedron Letters p. 6361 - 6364 (1989)

Update date:2022-08-03

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Authors:

Yamakage, Shun-ichi

Sakatsume, Osamu

Furuyama, Eiichi

Takaku, Hiroshi

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Article abstract of DOI:10.1016/S0040-4039(01)93894-8

The 1-(2-chloroethoxy)ethyl (Cee) group is completely stable under the acidic condition required to remove the 5'-protecting groups in oligonucleotide synthesis, but can be cleaved under the similar conditions to that of the tetrahydropyranyl (Thp) in the

Full text of DOI:10.1016/S0040-4039(01)93894-8

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