Cycloadducts of Ethene with 2(1H)-Pyrazinones and their conversion into 2,5-Diazabicyclooctane-3,6-diones.

Article abstract of DOI:10.1016/S0040-4020(01)96214-3

Cycloaddition of variously substituted 2(1H)-pyrazinones with ethene and subsequent hydrolysis of the adducts 2 provides a general and efficient route to the title compounds 3.Compound 3m was used as a building block for a structural analogue of gliotoxin