Chemical and Pharmaceutical Bulletin p. 2729 - 2733 (1991)
Update date:2022-08-04
Topics:
Kumazawa
Ohshima
Harakawa
Sato
Obase
Oiji
Ishii
Ishii
Ohmori
New methods for the preparation of multi-functionalized-6,11-dihydrodibenz[b,e]oxepins were developed. The structural requirements of KW-4994 (1), a promising orally active antiallergic agent, were defined. A carboxyl group at C-2 was critical for enhanced antiallergic activity of 1. The introduction of bromine atom at C-9 of 1 could elongate the duration of the action of the parent. Antiplatelet activity, a new pharmacological property of this series of compounds, was observed in one of the derivatives of 1.
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Doi:10.1016/0040-4039(91)80199-G
(1991)Doi:10.1055/s-1991-28412
(1991)Doi:10.1021/jo00031a004
(1992)Doi:10.1142/S1088424619501074
(2020)Doi:10.1021/ja00031a047
(1992)Doi:10.1155/2012/164235
(2012)
