A new series of antiallergic agents. II. Synthesis and activity of new 6,11-dihydrodibenz[b,e]oxepin-carboxylic acid derivatives

DOI: 10.1248/cpb.39.2729

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2729 - 2733 (1991)

Update date:2022-08-04

Topics:

Authors:

Kumazawa

Ohshima Ohshima

Harakawa

Sato Sato

Obase Obase

Oiji Oiji

Ishii Ishii

Ohmori Ohmori

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.39.2729

New methods for the preparation of multi-functionalized-6,11-dihydrodibenz[b,e]oxepins were developed. The structural requirements of KW-4994 (1), a promising orally active antiallergic agent, were defined. A carboxyl group at C-2 was critical for enhanced antiallergic activity of 1. The introduction of bromine atom at C-9 of 1 could elongate the duration of the action of the parent. Antiplatelet activity, a new pharmacological property of this series of compounds, was observed in one of the derivatives of 1.

Full text of DOI:10.1248/cpb.39.2729

NII-Electronic Library Service

Products guided by the article

Product name:Benzoic acid, 5-bromo-2-[[4-(methoxycarbonyl)phenoxy]methyl]-

Cas No:138639-75-5

R&D Labs maybe for 138639-75-5

GUANGZHOU MEDCAN PHARMATECH LTD

website:http://www.gzmedcan.com

Contact:+86-20-82519649

Address:Building J,Room 101,1 JiangtashanRd,Guang Zhou Science City,Guang Zhou ,China
Disynthesis Chemical Technology Co. Ltd.

Contact:+86-571-88194596

Address:Dengyun road 380, Gongshu district, Hangzhou city, China
Jinan Jinguilin Chemical Co.,Ltd

Contact:+86-531-81188412

Address:3rd floor of Torch Building, Huanyuan Rd, City of Jinan
NanJing Rate Biochemicals CO., LTD

Contact:+86-25-84931986

Address:NO. 1 Hongjing Road,Jiangning Science Park,Nanjing,China
Hebei Tete Trade Co., Ltd.

Contact:86-311-83160559

Address:shijiazhuang

Relevant to this article

AN EFFICIENT ROUTE TO C-4 LINKED IMIDAZOLE NUCLEOSIDES: SYNTHESIS OF 2-CARBAMOYL-4-(2'-DEOXY-β-D-RIBOFURANOSYL)IMIDAZOLE

Doi:10.1016/0040-4039(91)80199-G
(1991)
Synthesis of ethynylcyclopropanes from epoxides

Doi:10.1055/s-1991-28412
(1991)
Stereoselective Synthesis of Both Diastereomers of the α-Methyl-β-hydroxy-β-alkyl(aryl) Units by Use of Tin(II) Triflate-Mediated Aldol Reaction

Doi:10.1021/jo00031a004
(1992)
Meso -1,4-phenylene bridged nickel norcorrole dimer

Doi:10.1142/S1088424619501074
(2020)
Synthesis and structure determination of the adducts of the potent carcinogen 7,12-dimethylbenz[a]anthracene and deoxyribonucleosides formed by electrochemical oxidation: Models for metabolic activation by one-electron oxidation

Doi:10.1021/ja00031a047
(1992)
Synthesis, characterization and antimicrobial activity of imidazole derivatives based on 2-chloro-7-methyl-3-formylquinoline

Doi:10.1155/2012/164235
(2012)

Article Doi