Prodrugs of CL316243: A selective β3-adrenergic receptor agonist for treating obesity and diabetes

DOI: 10.1016/S0960-894X(99)00316-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1921 - 1926 (1999)

Update date:2022-07-29

Topics:

Authors:

Sum Sum

Gilbert Gilbert

Venkatesan

Lim Lim

Wong Wong

O'Dell O'Dell

Francisco

Chen Chen

Grosu Grosu

Baker Baker

Ellingboe

Malamas Malamas

Gunawan Gunawan

Primeau Primeau

Largis Largis

Steiner Steiner

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Article abstract of DOI:10.1016/S0960-894X(99)00316-9

CL316243 is a highly selective and potent β₃-adrenergic receptor agonist, and has been shown in rodent models to be an effective agent for treating obesity and Type II diabetes. To improve the oral absorption and pharmacokinetic profiles of CL316243, a number of prodrugs have been synthesized and evaluated. Several ester-type prodrugs show significant improvements in oral bioavailability in both rodent and primate models.

Full text of DOI:10.1016/S0960-894X(99)00316-9

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