Bioorganic and Medicinal Chemistry Letters p. 1921 - 1926 (1999)
Update date:2022-07-29
Topics:
Sum
Gilbert
Venkatesan
Lim
Wong
O'Dell
Francisco
Chen
Grosu
Baker
Ellingboe
Malamas
Gunawan
Primeau
Largis
Steiner
CL316243 is a highly selective and potent β3-adrenergic receptor agonist, and has been shown in rodent models to be an effective agent for treating obesity and Type II diabetes. To improve the oral absorption and pharmacokinetic profiles of CL316243, a number of prodrugs have been synthesized and evaluated. Several ester-type prodrugs show significant improvements in oral bioavailability in both rodent and primate models.
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