Tetrahedron p. 5169 - 5184 (1997)
Update date:2022-07-29
Topics:
Poujol, Helene
Ahond, Alain
Al Mourabit, Ali
Chiaroni, Angele
Poupat, Christiane
Riche, Claude
Potier, Pierre
Two new 7-deoxydocetaxel derivatives have been prepared from natural taxine B and isotaxine B: 2-debenzoyl-9-dihydro-1, 2,9,10-O-acetonide-7-deoxydocetaxel and 2-debenzoyl-1,2-O-acetonide-7-deoxy-10-acetyldocetaxel None of the compounds is cytotoxic: the second one, bearing one acetonide reveals a very weak microtubule disassembly inhibitory activity.
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