Taxoids: New derivatives of 7-deoxydocetaxel prepared from the alkaloids of yew

Article abstract of DOI:10.1016/S0040-4020(97)00180-4

Two new 7-deoxydocetaxel derivatives have been prepared from natural taxine B and isotaxine B: 2-debenzoyl-9-dihydro-1, 2,9,10-O-acetonide-7-deoxydocetaxel and 2-debenzoyl-1,2-O-acetonide-7-deoxy-10-acetyldocetaxel None of the compounds is cytotoxic: the second one, bearing one acetonide reveals a very weak microtubule disassembly inhibitory activity.