Structure-activity studies of morphine fragments. III. Synthesis, opiate receptor binding, analgetic activity and conformational studies of spiro-[tetralin-1,4'-piperidines]

Article abstract of DOI:10.1016/0223-5234(91)90003-6

A series of 5 spiro compounds, a new class of conformationally restricted analogs of 4-alkyl-4-(m-OH-phenyl) piperidines, have been synthesized and their affinities for μ, δ and κ opioid receptor sites and in vivo analgetic activities determined. All comp