Journal of the American Chemical Society p. 4179 - 4187 (1986)
Update date:2022-08-05
Topics: Reduction Amines Ligation Cytochrome P-450 Iron(III) Porphyrins Monoamine Oxidase
Castro, C. E.
Jamin, Mary
Yokoyama, W.
Wade, Ruth
The scope and mechanism of the ligation and reduction of iron(III) porphyrins by amines are presented.The reaction is general and proceeds with the overall stoichiometry 2PFe(III)Cl + 5RNH2 -> 2PFe(II)(H2NR)2 + R'CH=NH + 2RNH3(1+)Cl(1-).Imines are the only amine-derived products.The ability of the amine to coordinate iron and its possession of a >CHNH moiety are essential for reduction.The reaction path antails two successive reversible ligation steps followed by two one-electron reductions of the bis(amine)-ligated low-spin iron(III) adduct.In benzene the kinetics are biphasic.The second ligation is rate limiting
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