Novel Approach to the Ring-Opening of 4-Isoxazolines: One-Pot Synthesis of α,β-Enones

Article abstract of DOI:10.1016/S0040-4020(01)80585-8

Treatment of 4-isoxazoline derivatives with methyl iodide affords α,β-enones in excellent yields.The novel rearrangement pathway, through an intermediate isoxazolinium salt, is interpretable on the basis of the base removal of the hydrogen atom at N-CH3 group.