Bioorganic and Medicinal Chemistry Letters p. 5818 - 5823 (2014)
Update date:2022-07-29
Topics:
Trani, Giancarlo
Barker, John J.
Bromidge, Steven M.
Brookfield, Frederick A.
Burch, Jason D.
Chen, Yuan
Eigenbrot, Charles
Heifetz, Alexander
Ismaili, M. Hicham A.
Johnson, Adam
Krülle, Thomas M.
Mackinnon, Colin H.
Maghames, Rosemary
McEwan, Paul A.
Montalbetti, Christian A.G.N.
Ortwine, Daniel F.
Prez-Fuertes, Yolanda
Vaidya, Darshan G.
Wang, Xiaolu
Zarrin, Ali A.
Pei, Zhonghua
Starting from benzylpyrimidine 2, molecular modeling and X-ray crystallography were used to design highly potent inhibitors of Interleukin-2 inducible T-cell kinase (ITK). Sulfonylpyridine 4i showed sub-nanomolar affinity against ITK, was selective versus Lck and its activity in the Jurkat cell-based assay was greatly improved over 2.
View MoreSICHUAN ZHONGBANG NEW MATERIAL CO., LTD
website:http://www.zhongbangst.com
Contact:86-830-2585019
Address:sichuan,china
Mollt Biochem Co., Ltd(expird)
Contact:+86-21-38682181
Address:shanghai ,china
Yangzhou Siyu Chemical Co.,Ltd.
Contact:+86-514-87325867 13358126196
Address:Room 620 Exposition Pavilion,No. 98 Huaihai Road,Guangling District,Yangzhou City, Jiangsu Province
Tianjin Emulsion Science&Technology Development Co.,Ltd
Contact:13901380442
Address:Vake Garden New Town New Yi Bai Road Beichen District Tianjin,China
website:http://www.konochem.com
Contact:86-29-86107037-8015
Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China
Doi:10.1021/ol302121w
(2012)Doi:10.1016/j.ejmech.2012.04.024
(2012)Doi:10.3184/174751912X13300109535030
(2012)Doi:10.1021/jacs.5b00936
(2015)Doi:10.1007/s11164-011-0413-9
(2012)Doi:10.1016/j.orgel.2011.12.014
(2012)