A one-pot synthesis of 2,2-difluorovinyl carbonyl compounds from 2,2,2-trifluoroethyl p-toluenesulfonate via 2,2-difluorovinylboranes

Article abstract of DOI:10.1016/S0040-4039(00)74125-6

2,2,2-Trifluoroethyl p-toluenesulfonate is treated with butyllithium and trialkylboranes successively to generate 1-alkyl-2,2-difluorovinylboranes, which in turn react with acyl chlorides or chlorides or chloroformates in the presence of cuprous iodide to affort 2,2-difluorovinyl carbonyl compounds in good yields.