Multi-gram synthesis of a porphyrazine platform for cellular translocation, conjugation to Doxorubicin, and cellular uptake

DOI: 10.1016/j.tetlet.2012.07.087

Source and publish data:

Tetrahedron Letters p. 5475 - 5478 (2012)

Update date:2022-07-29

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Authors:

Trivedi, Evan R.

Blumenfeld, Carl M.

Wielgos, Todd

Pokropinski, Sharon

Dande, Prasad

Hai, Ton T.

Barrett, Anthony G.M.

Hoffman, Brian M.

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Article abstract of DOI:10.1016/j.tetlet.2012.07.087

We report the synthesis of the near infrared (NIR) fluorescent porphyrazine (Pz) 285, with pendant hydroxyl groups, as a non-toxic platform for delivery of conjugated chemotherapeutic agents to tumor cells. Conjugation of Pz 285 to Doxorubicin via an acid

Full text of DOI:10.1016/j.tetlet.2012.07.087

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