A one-pot generation of α-chloro-α-lithio alkanephosphonates. A new preparative route to 1,2-epoxyalkanephosphonates

Article abstract of DOI:10.1080/00397919208019263

Reaction of lithio anion derived from diethyl alkanephosphonate in the presence of 2 eq. of n-BuLi with benzenesulfonyl chloride gives directly the corresponding diethyl-1-chloro-1-lithioalkanephosphonate, which reacts in situ with carbonyl compounds followed by intramolecular substitution reaction to give 1,2-epoxyalkanephosphonates.

Full text of DOI:10.1080/00397919208019263

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A One-Pot Generation
of α-Chloro-α-Lithio
Alkanephosphonates. A New
Preparative Route to 1,2-
Epoxyalkanephosphonates
Kilsung Lee a , Won Suk Shin a & Dong Young Oh a
a Department of Chemistry , Korea Advanced
Institute of Science & Technology , P.O. Box 150,
Cheongyang-Ni, Seoul, 130-650, Korea
Published online: 24 Sep 2006.
To cite this article: Kilsung Lee , Won Suk Shin & Dong Young Oh (1992) A One-Pot
Generation of α-Chloro-α-Lithio Alkanephosphonates. A New Preparative Route
to 1,2-Epoxyalkanephosphonates, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 22:4, 649-655, DOI:
10.1080/00397919208019263
To link to this article: http://dx.doi.org/10.1080/00397919208019263
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