Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic

DOI: 10.1016/j.bmc.2015.03.074

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2839 - 2847 (2015)

Update date:2022-08-03

Topics: Photoactive

Authors:

Wagner, Stefan

Schütz, Anja

Rademann, J?rg

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Article abstract of DOI:10.1016/j.bmc.2015.03.074

Phosphopeptide mimetics containing the 4-phosphonocarbonyl phenylalanine (pcF) as a photo-active phosphotyrosine isoster are developed as potent, light-switchable inhibitors of the protein tyrosine phosphatase PTP1B. The photo-active inhibitors 6-10 are d

Full text of DOI:10.1016/j.bmc.2015.03.074

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