
Journal of the Chemical Society. Chemical communications p. 242 - 244 (1992)
Update date:2022-07-29
Topics:
Leeper, Finian J.
Rock, Martin
Syntheses are described of two analogues of porphobilinogen (PBG), a fluoro derivative 10 and a phosphonate 13, which are the first known unnatural substrates of PBG deaminase; when they act as inhibitors of the reaction of PBG, these compounds produce unusual sigmoidal kinetics, explained by their involvement as poor substrates in the particular mechanism of this enzyme.
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