4'-Modified Analogues of Aristeromycin and Neplanocin A: Synthesis and Inhibitory Activity toward S-Adenosyl-L-homocysteine Hydrolase

DOI: 10.1021/jm00088a013

Source and publish data:

Journal of Medicinal Chemistry p. 1782 - 1791 (1992)

Update date:2022-08-03

Topics:

Authors:

Wolfe, Michael S.

Lee, Younha

Bartlett, William J.

Borcherding, David R.

Borchardt, Ronald T.

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Article abstract of DOI:10.1021/jm00088a013

The carbocyclic adenosine analogues aristeromycin and neplanocin A both display significant S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitory activity and broad-spectrum antiviral effects.Since phosphorylation of the 4'-hydroxymethyl substituent has

Full text of DOI:10.1021/jm00088a013

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