Structure-activity relationships among a new class of antiviral heterosubstituted 2',3'-dideoxynucleoside analogues

Article abstract of DOI:10.1080/15257779508012439

3'-Oxa-4'-thiocytidine nucleoside analogues 14-17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of cell lines. Compound 16 is moderately active against HBV in 2.2.15 cells.

Full text of DOI:10.1080/15257779508012439

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Nucleosides and Nucleotides
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Structure-Activity Relationships Among a
New Class of Antiviral Heterosubstituted
2′,3′-Dideoxynucleoside Analogues
Tarek S. Mansour a , Haolun Jin a , Wei Wang a , Dilip M. Dixit a
,
Colleen A. Evans a , H. L. Allan Tse a , Bernard Belleau a , John W.
Gillard a , Elizabeth Hooker b , Claire Ashman b , Nick Cammack b
,
Horacio Salomon c , Antonietta R. Belmonte c & Mark A. Wainberg c
a BioChem Therapeutic Inc. , 275 Armand-Frappier Boulevard, Laval
(Quebec), Canada , H7V 4A7
b Department of Virology, Glaxo Research and Development Ltd. ,
Greenford Road, Greenford, Middlesex, United Kingdom , UB6 OHE
c Lady Davis Institute - Jewish General Hospital, and McGill AIDS
Centre, McGill University , Montreal, Quebec, Canada , H3T 1E2
Published online: 16 Feb 2007.
To cite this article: Tarek S. Mansour , Haolun Jin , Wei Wang , Dilip M. Dixit , Colleen A. Evans , H.
L. Allan Tse , Bernard Belleau , John W. Gillard , Elizabeth Hooker , Claire Ashman , Nick Cammack ,
Horacio Salomon , Antonietta R. Belmonte & Mark A. Wainberg (1995) Structure-Activity Relationships
Among a New Class of Antiviral Heterosubstituted 2′,3′-Dideoxynucleoside Analogues, Nucleosides
and Nucleotides, 14:3-5, 627-635
To link to this article: http://dx.doi.org/10.1080/15257779508012439
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