Synthesis of Hindered Secondary Amines via Grignard Reagent Addition to Ketonitrones

DOI: 10.1016/S0040-4039(00)91707-6

Source and publish data:

Tetrahedron Letters p. 1689 - 1692 (1992)

Update date:2022-08-04

Topics:

Authors:

Schwartz, Martin A.

Hu, Xiufeng

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Article abstract of DOI:10.1016/S0040-4039(00)91707-6

Grignard reagents add to ketonitrones in a nonpolar solvent to afford N,N-dialkylhydroxylamines in good yields and with little competing proton transfer.Deoxygenation of the crude hydroxylamines with carbon disulfide then completes an efficient general sy

Full text of DOI:10.1016/S0040-4039(00)91707-6

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