Enantioselective Formation of cis-3,5-Dimethylcyclohexanone Lithium Enolate and Stereoselective Aldol Reaction with Benzaldehyde

DOI: 10.1021/jo00039a018

Source and publish data:

Journal of Organic Chemistry p. 3599 - 3605 (1992)

Update date:2022-08-02

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Authors:

Majewski, Marek

Gleave, D. Mark

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Article abstract of DOI:10.1021/jo00039a018

Deprotonation of cis-3,5-dimethylcyclohexanone (6) with chiral lithium amide bases 10-12 has been investigated.The resulting lithium enolates 7a,b react with benzaldehyde, acetic anhydride, or trimethylsilyl chloride to yield, respectively, the aldols 8 a

Full text of DOI:10.1021/jo00039a018

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