Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3- chlorophenyl)piperazines for 5-HT(1A) receptor site

Article abstract of DOI:10.1021/jm00091a004

The effect of the hydrocarbon chain of the model 4-substituted 1-(3- chlorophenyl)piperazines 12-31 on their affinity for 5-HT(1A) receptor sites was investigated. It was found that elongation of the 4-n-alkyl chain strongly increases the 5-HT(1A) affinit