Synthesis and anti-HIV activity of isonucleosides

DOI: 10.1021/jm00091a001

Source and publish data:

Journal of Medicinal Chemistry p. 2347 - 2354 (1992)

Update date:2022-08-04

Topics: Synthesis Reagent Scaffold Experimental conditions Replication Anti-HIV activity Nucleoside analog

Authors:

Huryn Huryn

Sluboski

Tam Tam

Weigele Weigele

Sim Sim

Anderson

Mitsuya Mitsuya

Broder Broder

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Article abstract of DOI:10.1021/jm00091a001

A series of isomeric 2',3'-dideoxynucleosides which contains a modified carbohydrate moiety has been prepared. This class of compounds was designed to mimic the activity of known anti-HIV dideoxynucleosides, while imparting enhanced chemical and enzymatic

Full text of DOI:10.1021/jm00091a001

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Product name:(2R-cis)-1--5-methyl-2,4-(1H,3H)-pyrimidinedione

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