An unusual twist in the synthesis and hydrolysis of the 23,24-epoxide of 22,23-dihydroavermectinB(1a)

DOI: 10.1016/S0040-4039(00)91712-X

Source and publish data:

Tetrahedron Letters p. 1709 - 1712 (1992)

Update date:2022-08-06

Topics:

Authors:

Shih Shih

Mrozik Mrozik

Holmes Holmes

Arison Arison

Doss Doss

Waksmunski

Fisher Fisher

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Article abstract of DOI:10.1016/S0040-4039(00)91712-X

Treatment of 4'',5-di-O-tert-butyldimethylsilyl (or phenoxyacetyl)-7-O-trimethylsilyl-avermectin B(2a) (1a,b) with diethylaminosulfur trifluoride (DAST) at 20AC in dichloromethane resulted in net elimination of water to yield 65% of the 23,24-olefin (2a,b

Full text of DOI:10.1016/S0040-4039(00)91712-X

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