Stereochemical Control of Enzymatic Carbon–Carbon Bond-Forming Michael-Type Additions by “Substrate Engineering”

DOI: 10.1002/ejoc.201601126

Source and publish data:

European Journal of Organic Chemistry p. 5350 - 5354 (2016)

Update date:2022-09-26

Topics:

Authors:

Miao, Yufeng

Tepper, Pieter G.

Geertsema, Edzard M.

Poelarends, Gerrit J.

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Article abstract of DOI:10.1002/ejoc.201601126

The enzyme 4-oxalocrotonate tautomerase (4-OT) promiscuously catalyzes the Michael-type addition of acetaldehyde to β-nitrostyrene derivatives to yield chiral γ-nitroaldehydes, which are important precursors for pharmaceutically active γ-aminobutyric acid

Full text of DOI:10.1002/ejoc.201601126

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