DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of (1,2-diaminoethane)dichloroplatinum(II)

DOI: 10.1021/jm00094a008

Source and publish data:

Journal of Medicinal Chemistry p. 2983 - 2987 (1992)

Update date:2022-07-30

Topics: DNA-directed alkylating agents

Authors:

Lee Lee

Palmer Palmer

Baguley Baguley

Chin Chin

McFadyen

Wickham Wickham

Thorsbourne-Palmer

Wakelin Wakelin

Denny Denny

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Article abstract of DOI:10.1021/jm00094a008

A series of acridine-2- and -4-carboxamide-linked analogues of PtenCl₂ has been prepared and evaluated for biological activity against several tumor cell lines in vitro and in vivo. The platinum complexes were generally more cytotoxic than the

Full text of DOI:10.1021/jm00094a008

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