DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of (1,2-diaminoethane)dichloroplatinum(II)

Article abstract of DOI:10.1021/jm00094a008

A series of acridine-2- and -4-carboxamide-linked analogues of PtenCl₂ has been prepared and evaluated for biological activity against several tumor cell lines in vitro and in vivo. The platinum complexes were generally more cytotoxic than the