Journal of Organic Chemistry p. 11212 - 11218 (2015)
Update date:2022-08-04
Topics:
Rassokhina, Irina V.
Shirinian, Valerii Z.
Zavarzin, Igor V.
Gevorgyan, Vladimir
Volkova, Yulia A.
A single copper(II)-catalyzed three-component cascade aminomethylation/cycloisomerization of propiolates to form imidazo[1,2-a]pyridines was explored. A straightforward method was developed for the practical synthesis of functionalized imidazo[1,2-a]pyridines from benzaldehydes, 2-aminopyridines, and propiolate derivatives catalyzed by Cu(OAc)2 hydrate in the presence of air. The protocol is marked by excellent yields, functional group tolerance, and, above all, adaptability to synthesize imidazo[1,2-a]pyridine-based drug molecules such as Alpidem.
View MoreSuZhou Hua-Emy Chemical Import and Export Co., LTD.
Contact:+86-512-88804994; +86-512-88804550;
Address:710, Building B, International Trade Center, 12 Huanghelu, Changshu, Jiangsu,China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)
Contact:+86-21-54159691
Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
Jiangsu Glory Chemical Co., Ltd.
Contact:+86-571-87896791
Address:Yanhua Chemical Park, Hongze, Huai'an, Jiangsu, China
Contact:021-36356756
Address:Room601,Building No.14,280 Yangcheng Road,Shanghai
Doi:10.1016/0223-5234(92)90107-C
(1992)Doi:10.1246/bcsj.68.2401
(1995)Doi:10.1016/S0040-4039(00)78872-1
(1992)Doi:10.1055/s-2002-33328
(2002)Doi:10.1016/j.tetlet.2013.01.039
(2013)Doi:10.1016/0040-4039(92)88156-Y
(1992)