A convenient approach for the synthesis of 2,6-diformyl- and 2,6-diacetylpyridines

Article abstract of DOI:10.1016/j.tetlet.2012.11.004

2,6-Diformyl- and 2,6-diacetylpyridines are readily accessed in good yields (60-90%) via the single-pot reaction of 2,6-pyridine dicarboxamides with LiAlH₄ or MeMgCl in THF at 0-20°C. The high efficiency of the method illustrates the significance of solubility in the reduction and alkylation of difunctionalized substrates.