PREPARATION OF (1R,4R)-1-METHYL-2-(p-TOLUENESULFONYL)-5-PHENYLMETHYL-2,5-DIAZABICYCLOHEPTANE, INTERMEDIATE IN A SYNTHESIS OF NEW NAPHTHYRIDONES

Article abstract of DOI:10.3987/COM-92-5984

An efficient chiral synthesis of the (1R,4R)-1-methyl-2-(p-toluenesulfonyl)-5-phenylmethyl-2,5-diazabicyclo<2.2.1>heptane (2b) was performed using trans-4-hydroxy-L-proline as starting material.This bridged piperazine was used in the preparation of new na