Journal of Organic Chemistry p. 4932 - 4939 (1992)
Update date:2022-08-05
Topics:
Katritzky, Alan R.
Rachwal, Stanislaw
Rachwal, Bogumila
Steel, Peter J.
1-(α-Aminoalkyl)benzotriazoles add readily to enol ethers to give the corresponding 1-benzotriazolyl-3-aminoalkylethers in high yields.Subsequent replacement of the benzotriazole moiety by an alkyl or aryl group (with a Grignard reagent) or by a hydrogen atom (with lithium aluminum hydride) affords 1,3-amino-ethers in good yields.Anchimeric assistance by the amino groups in the substitutions of the benzotriazolyl moiety facilitates the reactions.Full stereochemistry is assigned to the stereoisomeric products on the basis of NMR techniques and X-ray diffraction.
View MoreEvergreen Chemical Industry Ltd.
Contact:86-553-4918210
Address:6#2-602 Wanhaobailing
Huaian Double Win Chemicals Co.,Ltd.
Contact:+86-13511538872
Address:Blk 43,Greenland Century Town,Huaian District, Huaian City,Jiangsu Province,China
Contact:86-310-8067016
Address:East Fuhua Road,Tiexi Chemical Industrial Estate,Hebei,China
Tianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)(expird)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Beijing Harmony Chemical Co., Ltd.
Contact:86-010-84956928
Address:Room 207, Jin feng he B building, No 8 Xin Jie Kou Wai Street, Xi Cheng District, Beijing,PRC. 10008
Doi:10.1002/anie.201402470
(2014)Doi:10.1021/ja908749u
(2010)Doi:10.1021/jo952078h
(1996)Doi:10.1021/jo01275a065
(1968)Doi:10.1021/jm960092w
(1996)Doi:10.1246/bcsj.42.3204
(1969)