Journal of Organic Chemistry p. 4932 - 4939 (1992)
Update date:2022-08-05
Topics:
Katritzky, Alan R.
Rachwal, Stanislaw
Rachwal, Bogumila
Steel, Peter J.
1-(α-Aminoalkyl)benzotriazoles add readily to enol ethers to give the corresponding 1-benzotriazolyl-3-aminoalkylethers in high yields.Subsequent replacement of the benzotriazole moiety by an alkyl or aryl group (with a Grignard reagent) or by a hydrogen atom (with lithium aluminum hydride) affords 1,3-amino-ethers in good yields.Anchimeric assistance by the amino groups in the substitutions of the benzotriazolyl moiety facilitates the reactions.Full stereochemistry is assigned to the stereoisomeric products on the basis of NMR techniques and X-ray diffraction.
View MoreAnhui Asahikasei Chemical Co., Ltd
Contact:86-551-4259770
Address:No. 88 Linquan Road Hefei Anhui China
Suzhou Sibian Chemical Technology Co., Ltd
website:http://www.sibianpharm.com
Contact:+8618169181984,+8618013186906
Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
VanderArk International Limited
Contact:86-10-82437576
Address:Qing He
Baoding Lanpa Metal Surface Finishing Co.,Ltd
Contact:86-0312-6795087
Address:Tianwei West Street
Contact:86-516-66656369
Address:The west road of Huaihai, Xuzhou, China
Doi:10.1002/anie.201402470
(2014)Doi:10.1021/ja908749u
(2010)Doi:10.1021/jo952078h
(1996)Doi:10.1021/jo01275a065
(1968)Doi:10.1021/jm960092w
(1996)Doi:10.1246/bcsj.42.3204
(1969)