N1-hydroxylated derivatives of chlorpropamide and its analogs as inhibitors of aldehyde dehydrogenase in vivo

DOI: 10.1021/jm00098a007

Source and publish data:

Journal of Medicinal Chemistry p. 3641 - 3647 (1992)

Update date:2022-09-26

Topics:

Authors:

Lee Lee

Elberling

Nagasawa

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Article abstract of DOI:10.1021/jm00098a007

Certain (arylsulfonyl)urea hypoglycemic drugs exemplified by chlorpropamide (CP) are known to interact pharmacologically with alcohol (ethanol) to elicit a chlorpropamide-alcohol flushing (CPAF) reaction that is reminiscent of the disulfiram-ethanol react

Full text of DOI:10.1021/jm00098a007

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