
Synthetic Communications p. 2119 - 2126 (2013)
Update date:2022-09-26
Topics:
Zhang, Yan-Feng
Han, Xiao-Dan
Ren, Chuan-Qing
Zhao, Yu-Long
A novel and efficient copper(I)-catalyzed three-component Huisgen cycloaddition reaction of conjugated enynes, alkyl halides, and sodium azide has been developed. These reactions were performed in the absence of amide ligands at room temperature, and the corresponding mono-and bis-1,2,3-triazoles were obtained in good to excellent yields in a one-pot procedure. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
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