Rhodium-catalyzed asymmetric amination of allylic trichloroacetimidates

Article abstract of DOI:10.1055/s-0032-1316921

A summary is presented of dynamic kinetic asymmetric transformations of racemic allylic trichloroacetimidates in the presence of chiral diene-ligated rhodium catalysts. The reaction is applicable to a wide variety of secondary and tertiary trichloroacetimidates containing aniline or benzylamine nucleophiles, affording nitrogen-containing tertiary and quaternary centers in good yields and with high levels of regio- and enantioselectivity. This catalytic method addresses many of the limitations previously associated with syntheses of these compounds. Georg Thieme Verlag Stuttgart - New York.