Synthetic Communications p. 1439 - 1446 (2013)
Update date:2022-08-04
Topics:
Hackenmueller, Sarah A.
Scanlan, Thomas S.
Thyroid hormones undergo extensive metabolism to regulate hormone activity. A labeled thyroid hormone would be useful to track hormone metabolism through various pathways. While radiolabeled thyroid hormones have been synthesized and used for in vivo studies, a stable isotope labeled form of thyroid hormone is required for studying thyroid hormone metabolism by LC-MS/MS, an analytical technique that has certain advantages without the complications of radioactivity. Here we report the synthesis of 13C9- 15N-T2 and 13C9-15N- T4, two labeled thyroid hormone derivatives suitable for in vivo LC-MS/MS studies. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
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Doi:10.1248/cpb.40.1130
(1992)Doi:10.1002/chem.201204235
(2013)Doi:10.1039/c3ra23052j
(2013)Doi:10.1021/acs.joc.7b02179
(2017)Doi:10.1021/acschemneuro.7b00098
(2017)Doi:10.1021/ol401061v
(2013)