Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists

DOI: 10.1021/jm00100a015

Source and publish data:

Journal of Medicinal Chemistry p. 4092 - 4097 (1992)

Update date:2022-07-29

Topics:

Authors:

Melikian

Schlewer

Chambon Chambon

Wermuth Wermuth

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Article abstract of DOI:10.1021/jm00100a015

Ten analogs of muscimol and thiomuscimol in which the amino function was delocalized in an amidinic system were prepared by N2 alkylation of 6-aryl-3- aminopyridazines with (chloromethyl)isoxazole or (chloromethyl)isothiazole derivatives. These muscimol a

Full text of DOI:10.1021/jm00100a015

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Article Doi

Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists

DOI: 10.1021/jm00100a015

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jm00100a015

Full text of DOI:10.1021/jm00100a015

Products guided by the article

R&D Labs maybe for 143268-43-3

Relevant to this article

Candida antarctica lipase B catalyzed enantioselective acylation of pyrimidine acyclonucleoside

Copper-catalysed direct radical alkenylation of alkyl bromides

Visible-light photocatalytic radical alkenylation of a-carbonyl alkyl bromides and benzyl bromides

Synthesis and antimicrobial activity of 3-(substituted-phenyl)-sydnones

Spectroscopic characterization of (diiodomethyl)zinc iodide: Application to the stereoselective synthesis and functionalization of iodocyclopropanes

Amino acids, XII: (±)Pipecolic acid derivatives - Part 2: An expedient synthetic entry to substituted pipecolic acids