Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists

DOI: 10.1021/jm00100a015

Source and publish data:

Journal of Medicinal Chemistry p. 4092 - 4097 (1992)

Update date:2022-07-29

Topics:

Authors:

Melikian

Schlewer

Chambon Chambon

Wermuth Wermuth

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Article abstract of DOI:10.1021/jm00100a015

Ten analogs of muscimol and thiomuscimol in which the amino function was delocalized in an amidinic system were prepared by N2 alkylation of 6-aryl-3- aminopyridazines with (chloromethyl)isoxazole or (chloromethyl)isothiazole derivatives. These muscimol a

Full text of DOI:10.1021/jm00100a015

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