Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists

DOI: 10.1021/jm00100a015

Source and publish data:

Journal of Medicinal Chemistry p. 4092 - 4097 (1992)

Update date:2022-07-29

Topics:

Authors:

Melikian

Schlewer

Chambon Chambon

Wermuth Wermuth

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00100a015

Ten analogs of muscimol and thiomuscimol in which the amino function was delocalized in an amidinic system were prepared by N2 alkylation of 6-aryl-3- aminopyridazines with (chloromethyl)isoxazole or (chloromethyl)isothiazole derivatives. These muscimol a

Full text of DOI:10.1021/jm00100a015

Products guided by the article

Product name:3(2H)-Isothiazolone, 5-[(6-imino-3-methyl-4-phenyl-1(6H)-pyridazinyl)methyl]-, monohydrobromide

Cas No:143268-43-3

R&D Labs maybe for 143268-43-3

Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China
Changzhou Anyi Biochem Co., Ltd.(expird)

Contact:+86-519-88836158

Address:no,51 caoda
Shanghai Haoyuan Chemexpress Co., Ltd.

website:https://www.chemexpress.com/

Contact:86-21-58950125

Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203
Forsman Scientific(Beijing)co.,Ltd.

Contact:+86-10-64646565

Address:Rm No.1301, Building-2, No. A-13 Beiyuan Road, Chaoyang District Beijing, China, PR,
Sinochem Jiangsu Co.,Ltd.

Contact:86-25-51817806

Address:No. 216, middle longpan road, jincheng tower, floor 21-22, nanjing ,china

Relevant to this article

Candida antarctica lipase B catalyzed enantioselective acylation of pyrimidine acyclonucleoside

Doi:10.3109/10242422.2012.715637
(2012)
Copper-catalysed direct radical alkenylation of alkyl bromides

Doi:10.1039/c4ob00813h
(2014)
Visible-light photocatalytic radical alkenylation of a-carbonyl alkyl bromides and benzyl bromides

Doi:10.1002/chem.201203694
(2013)
Synthesis and antimicrobial activity of 3-(substituted-phenyl)-sydnones

Doi:10.1002/ardp.19923250706
(1992)
Spectroscopic characterization of (diiodomethyl)zinc iodide: Application to the stereoselective synthesis and functionalization of iodocyclopropanes

Doi:10.1039/c7cc04348a
(2017)
Amino acids, XII: (±)Pipecolic acid derivatives - Part 2: An expedient synthetic entry to substituted pipecolic acids

Doi:10.1002/ardp.19923250709
(1992)

Article Doi