Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists

DOI: 10.1021/jm00100a015

Source and publish data:

Journal of Medicinal Chemistry p. 4092 - 4097 (1992)

Update date:2022-07-29

Topics:

Authors:

Melikian

Schlewer

Chambon Chambon

Wermuth Wermuth

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00100a015

Ten analogs of muscimol and thiomuscimol in which the amino function was delocalized in an amidinic system were prepared by N2 alkylation of 6-aryl-3- aminopyridazines with (chloromethyl)isoxazole or (chloromethyl)isothiazole derivatives. These muscimol a

Full text of DOI:10.1021/jm00100a015

Products guided by the article

Product name:3(2H)-Isothiazolone, 5-[(6-imino-3-methyl-4-phenyl-1(6H)-pyridazinyl)methyl]-, monohydrobromide

Cas No:143268-43-3

R&D Labs maybe for 143268-43-3

guide(suzhou) fine materials co. ltd

Contact:0512-80972173

Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
Nanjing Ruizhi Industry & Technologh Co.，Ltd.

Contact:+86-25-86808110

Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
Taizhou Green Peptide Trading Co., Ltd.

Contact:--

Address:Room 1501, No71, Yuehe Road, Taizhou City, Zhejiang Province, China
Beijing Stable Chemcial Co.ltd

Contact:86-10-63785052

Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China
Zhejiang Chemline International Co., Ltd.

Contact:+86-571-88062298

Address:Hengdian Industry Area, Dongyang, Zhejiang, China

Relevant to this article

Candida antarctica lipase B catalyzed enantioselective acylation of pyrimidine acyclonucleoside

Doi:10.3109/10242422.2012.715637
(2012)
Copper-catalysed direct radical alkenylation of alkyl bromides

Doi:10.1039/c4ob00813h
(2014)
Visible-light photocatalytic radical alkenylation of a-carbonyl alkyl bromides and benzyl bromides

Doi:10.1002/chem.201203694
(2013)
Synthesis and antimicrobial activity of 3-(substituted-phenyl)-sydnones

Doi:10.1002/ardp.19923250706
(1992)
Spectroscopic characterization of (diiodomethyl)zinc iodide: Application to the stereoselective synthesis and functionalization of iodocyclopropanes

Doi:10.1039/c7cc04348a
(2017)
Amino acids, XII: (±)Pipecolic acid derivatives - Part 2: An expedient synthetic entry to substituted pipecolic acids

Doi:10.1002/ardp.19923250709
(1992)

Article Doi