Journal of Medicinal Chemistry p. 3341 - 3344 (1992)
Update date:2022-08-04
Topics:
Goldmann
Stoltefuss
Born
The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2- phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.
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Doi:10.1107/S0108270113002503
()Doi:10.1021/jo00046a032
(1992)Doi:10.1021/acs.jmedchem.5b00910
(2015)Doi:10.1039/jr9350001840
(1935)Doi:10.1021/jo400481b
(2013)Doi:10.1016/0040-4039(92)80021-B
(1992)
