Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: A correction

DOI: 10.1021/jm00096a005

Source and publish data:

Journal of Medicinal Chemistry p. 3341 - 3344 (1992)

Update date:2022-08-04

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Authors:

Goldmann

Stoltefuss

Born Born

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Article abstract of DOI:10.1021/jm00096a005

The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2- phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.

Full text of DOI:10.1021/jm00096a005

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