Chemical degradation of steroid side chains. Efficient conversion of cholestanol to corticosteroid intermediates.

Article abstract of DOI:10.1016/S0040-4039(00)74674-0

17-Chlorosteroids, produced by template-directed halogenation of 9-fluoro 11-oxygenated cholestanols that are themselves produced by template methods, are converted to their 17-keto analogs in high yields (85-91%) after HCl elimination with DBU, followed by ozonolysis.