Stereocontrolled Route to the δ-Benzylidenemethyl-β-hydroxy-δ-lactone System Utilizing a New Chiral Epoxyacetylene Building Block

DOI: 10.1016/S0957-4166(00)82182-5

Source and publish data:

Tetrahedron Asymmetry p. 853 - 856 (1992)

Update date:2022-09-26

Topics:

Authors:

Takano, Seiichi

Kamikubo, Takashi

Sugihara, Takumichi

Ogasawara, Kunio

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0957-4166(00)82182-5

Stereocontrolled route to the δ-benzylidenemethyl-β-hydroxy-δ-lactone system has been developed utilizing a new epoxyacetylene building block prepared from optically active epichlorohydrin.The present synthesis allowed efficient construction of goniothalamin in natural and unnatural forms and its 3-hydroxy derivative having the essential anti-β/δ-stereochemistry for HMG Co-A reductase inhibition.

Full text of DOI:10.1016/S0957-4166(00)82182-5

Products guided by the article

Product name:(S)-1-Phenyl-1-phenylsulfanyl-6-trimethylsilanyl-hex-5-yn-3-ol

Cas No:143724-98-5

R&D Labs maybe for 143724-98-5

Xi'an North Information Industry Co., Ltd. Weilv Chemical Department

Contact:+86-29-88156413

Address:Jixiang Road 99 Xi'an Shaanxi Province
HANGZHOU GOPHER CHEM-TECH CO.,LTD

Contact:86-189-58111780

Address:Da Cheng Ming Zuo Plaza,Xiaoshan District
Luojiang Chenming Biological Products Co

Contact:+86 15000297032

Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
Weifang Jahwa Chemical Co.,Ltd

Contact:0086-536-8897731,8897730

Address:No.5166 East Dongfeng Street,Weifang,Shandong,China

Relevant to this article

N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine

Doi:10.1021/jo400788a
(2013)
Synthesis and characterization of carbonyl group-6-metal derivatives with ligand N,N-Bis(diphenylphosphino)naphthalen-1-amine (=N-(Diphenylphosphino)-N- naphthalen-1-yl-P,P-diphenylphosphinous Amide). molecular structure of cis-tetracarbonyl[N-(diphenylphosphino-κP)-N-naphthalen-1-yl-P,P-diphenylphosphinous amide-κP]molybdenum (cis-[Mo(CO)₄{C

Doi:10.1002/hlca.201200315
(2013)
Synthesis and anticancer activity of aminodihydroquinoline analogs: Identification of novel proapoptotic agents

Doi:10.1016/j.bmcl.2013.04.038
(2013)
Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery

Doi:10.1016/j.bmc.2013.04.069
(2013)
CYTOCHALASINS U AND V, TWO NEW CYTOCHALASANS, FROM PHOMA EXIGUA VAR. HETEROMORPHA

Doi:10.1016/S0040-4020(01)88222-3
(1992)
Poly(thiophosphazenes): New inorganic macromolecules with backbones composed of phosphorus, nitrogen, and sulfur atoms

Doi:10.1021/ja00159a070
(1990)

Article Doi