
Tetrahedron Asymmetry p. 853 - 856 (1992)
Update date:2022-09-26
Topics:
Takano, Seiichi
Kamikubo, Takashi
Sugihara, Takumichi
Ogasawara, Kunio
Stereocontrolled route to the δ-benzylidenemethyl-β-hydroxy-δ-lactone system has been developed utilizing a new epoxyacetylene building block prepared from optically active epichlorohydrin.The present synthesis allowed efficient construction of goniothalamin in natural and unnatural forms and its 3-hydroxy derivative having the essential anti-β/δ-stereochemistry for HMG Co-A reductase inhibition.
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Doi:10.1021/jo400788a
(2013)Doi:10.1002/hlca.201200315
(2013)Doi:10.1016/j.bmcl.2013.04.038
(2013)Doi:10.1016/j.bmc.2013.04.069
(2013)Doi:10.1016/S0040-4020(01)88222-3
(1992)Doi:10.1021/ja00159a070
(1990)