Stereocontrolled Route to the δ-Benzylidenemethyl-β-hydroxy-δ-lactone System Utilizing a New Chiral Epoxyacetylene Building Block

DOI: 10.1016/S0957-4166(00)82182-5

Source and publish data:

Tetrahedron Asymmetry p. 853 - 856 (1992)

Update date:2022-09-26

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Authors:

Takano, Seiichi

Kamikubo, Takashi

Sugihara, Takumichi

Ogasawara, Kunio

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Article abstract of DOI:10.1016/S0957-4166(00)82182-5

Stereocontrolled route to the δ-benzylidenemethyl-β-hydroxy-δ-lactone system has been developed utilizing a new epoxyacetylene building block prepared from optically active epichlorohydrin.The present synthesis allowed efficient construction of goniothalamin in natural and unnatural forms and its 3-hydroxy derivative having the essential anti-β/δ-stereochemistry for HMG Co-A reductase inhibition.

Full text of DOI:10.1016/S0957-4166(00)82182-5

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