Synthesis of eukaryotic translation elongation inhibitor lactimidomycin via Zn(II)-mediated horner-wadsworth-emmons macrocyclization

DOI: 10.1021/ol401186f

Source and publish data:

Organic Letters p. 2998 - 3001 (2013)

Update date:2022-07-30

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Authors:

Larsen, Brian J.

Sun, Zhankui

Nagorny, Pavel

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Article abstract of DOI:10.1021/ol401186f

An enantioselective synthesis of potent eukaryotic translation elongation inhibitor lactimidomycin has been accomplished in 21 linear steps. This synthesis features a Zn(II)-mediated Horner-Wadsworth-Emmons reaction that could be executed on a large scale to provide the highly strained 12-membered lactimidomycin macrolactone.

Full text of DOI:10.1021/ol401186f

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