A REGIOSELECTIVE LITHIATION OF 1-METHOXYMETHOXYINDOLE AT THE 2-POSITION AND ITS APPLICATION FOR THE SYNTHESIS OF 2-SUBSTITUTED INDOLES

DOI: 10.3987/COM-92-6066

Source and publish data:

Heterocycles p. 1295 - 1298 (1992)

Update date:2022-08-03

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Authors:

Somei, Masanori

Kobayashi, Tetsuya

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Article abstract of DOI:10.3987/COM-92-6066

A regioselective lithiation of 1-methoxymethoxyindole at the 2-position was achieved with n-BuLi at 0 deg C.Subsequent treatment with electrophiles afforded 2-substituted 1-methoxymethoxyindoles, which were readily converted to 2-substituted indoles.

Full text of DOI:10.3987/COM-92-6066

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